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Loss of the tert-butyloxycarbonyl (Boc) protecting group under basic conditions

✍ Scribed by Timothy P. Curran; Michael P. Pollastri; Susan M. Abelleira; Renee J. Messier; Theresa A. McCollum; Campbell G. Rowe

Book ID: 104214730
Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 298 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73512-x

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✦ Synopsis

Abstruck Reaction of 3, the N-kc, 0-togrl derivative of phenylalaninol, with base leads to loss of the Boc and tosyl groups and kmnation of oxazdidinone 9. Similar mnctions Jmve also been examined. A medUlismtoeaplainlossoftheBocgn3Upunderbasic reactionEonditionsisprOpoWl.

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