Improved protection and esterification of a precursor of the taxotere® and taxol side chains

✍ Scribed by A. Commerçon; D. Bézard; F. Bernard; J.D. Bourzat

• Book ID: 104215782
• Publisher: Elsevier Science
• Year: 1992
• Tongue: French
• Weight: 271 KB
• Volume: 33
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)79128-3

✦ Synopsis

ilS.5R)-N-BOC-2,2-dinrethylI-phenyl-5-ox~oi~i~cu~oxy~ic acid 8 was prepared and efJiciently esterjied by conveniently pmtgted baccatins 9a,b. Smooth depmtection in formic acid gave the Ndepmtected intermediates of Taxotere and taxol. This C-2' und constitutes a pratical method to prepare