𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Highly Stereocontrolled and Efficient Preparation of the Protected, Esterification-Ready Docetaxel (Taxotere) Side Chain

✍ Scribed by Kanazawa, Alice M.; Denis, Jean-Noel; Greene, Andrew E.


Book ID
120179677
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
395 KB
Volume
59
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Catalytic asymmetric synthesis of the do
✍ Pawel Dziedzic; Jan Vesely; Armando Córdova 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 182 KB

A highly enantioselective catalytic route to protected b-amino-a-hydroxy acids, such as the side chain of Taxotere, is presented. The organocatalytic asymmetric reactions between unmodified protected aoxyaldehydes and N-Boc-protected aryl imines give the corresponding compound with up to >19:1 dr an

Improved protection and esterification o
✍ A. Commerçon; D. Bézard; F. Bernard; J.D. Bourzat 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 271 KB

ilS.5R)-N-BOC-2,2-dinrethylI-phenyl-5-ox~oi~i~cu~oxy~ic acid 8 was prepared and efJiciently esterjied by conveniently pmtgted baccatins 9a,b. Smooth depmtection in formic acid gave the Ndepmtected intermediates of Taxotere and taxol. This C-2' und constitutes a pratical method to prepare