A highly enantioselective catalytic route to protected b-amino-a-hydroxy acids, such as the side chain of Taxotere, is presented. The organocatalytic asymmetric reactions between unmodified protected aoxyaldehydes and N-Boc-protected aryl imines give the corresponding compound with up to >19:1 dr an
✦ LIBER ✦
Highly Stereocontrolled and Efficient Preparation of the Protected, Esterification-Ready Docetaxel (Taxotere) Side Chain
✍ Scribed by Kanazawa, Alice M.; Denis, Jean-Noel; Greene, Andrew E.
- Book ID
- 120179677
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 395 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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