Catalytic asymmetric synthesis of the do
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Pawel Dziedzic; Jan Vesely; Armando Córdova
📂
Article
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2008
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Elsevier Science
🌐
French
⚖ 182 KB
A highly enantioselective catalytic route to protected b-amino-a-hydroxy acids, such as the side chain of Taxotere, is presented. The organocatalytic asymmetric reactions between unmodified protected aoxyaldehydes and N-Boc-protected aryl imines give the corresponding compound with up to >19:1 dr an