An improved synthesis of the taxol side chain and of RP 56976
โ Scribed by Denis, Jean Noel; Correa, Arlene; Greene, Andrew E.
- Book ID
- 121453899
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 442 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Dihydrodihydroxycinnamic acids and their esters react with acetonitrile or benzonitrile in the presence of sulfuric acid to afford the corresponding syn-b-amino-a-hydroxypropionic acid derivatives. High yields and diastereoselectivity of this transformation allows preparation of various phenylisoser
Practical Synthesis of Taxol Side Chain. -A practical large-scale synthesis of the taxol side chain is achieved via the coupling of the chiral imine (V) with ketene acetal (II) followed by sequential reactions of lactamization, demethylation, methanolysis, and N-benzoylation. -(HA, H.-