An enantioselective synthesis of the acyl side-chain 3 of polyoxypeptins 1 and 2 was achieved by the Sharpless AE, with subsequent regioselective opening of the epoxyalcohol using a Grignard reagent in the presence of CuI, and an aldol condensation using Seebach's ester. The method reported has the
โฆ LIBER โฆ
An efficient, enantioselective synthesis of the taxol side chain
โ Scribed by Denis, Jean Noel; Greene, Andrew E.; Serra, A. Aarao; Luche, Marie Jacqueline
- Book ID
- 120624204
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 792 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3263
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