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A practical, highly enantioselective synthesis of the taxol side chain via asymmetric catalysis.

โœ Scribed by Deng, Li; Jacobsen, Eric N.


Book ID
118026544
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
634 KB
Volume
57
Category
Article
ISSN
0022-3263

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A highly stereocontrolled asymmetric syn
โœ Kee-Young Lee; Yong-Hyun Kim; Min-Sung Park; Won-Hun Ham ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 188 KB

A stereoselective synthesis of (4S, 5R)-2,4-diphenyloxazoline-5-carboxylic acid, a precursor of the Taxol C-13 side chain was achieved using palladium-catalyzed oxazoline formation reaction from commercially available amino acid.