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A highly stereocontrolled asymmetric synthesis of the Taxol C-13 side chain; (4S, 5R)-2,4-diphenyloxazoline-5-carboxylic acid

✍ Scribed by Kee-Young Lee; Yong-Hyun Kim; Min-Sung Park; Won-Hun Ham

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 188 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01804-8

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✦ Synopsis

A stereoselective synthesis of (4S, 5R)-2,4-diphenyloxazoline-5-carboxylic acid, a precursor of the Taxol C-13 side chain was achieved using palladium-catalyzed oxazoline formation reaction from commercially available amino acid.

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