Imprinted M6p/Igf2 receptor is mutated in rat liver tumors
✍ Scribed by Mills, J J; Falls, J G; De Souza, A T; Jirtle, R L
- Book ID
- 110061318
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 461 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
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M6P/IGF2R encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and cytotoxic T cell-induced apoptosis. M6P/IGF2R is imprinted and expressed only from the maternally inherited allele in marsupials and rodents. In contrast, humans were ini
## Abstract To elucidate whether the M6p/Igf2 receptor (M6p/Igf2r) gene might be involved in exogenous and endogenous liver carcinogenesis, we investigated its alteration in hepatocellular carcinomas (HCCs) induced by __N__‐nitrosodiethylamine (DEN) and by a choline‐deficient L‐amino acid‐defined (