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Impaired synaptic plasticity in a rat model of tuberous sclerosis

✍ Scribed by Christian Von Der Brelie; Robert Waltereit; Lian Zhang; Heinz Beck; Timo Kirschstein

Book ID: 109024314
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 186 KB
Volume: 23
Category: Article
ISSN: 0953-816X
DOI: 10.1111/j.1460-9568.2006.04594.x

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## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d