## Abstract Somatic events leading to the inactivation of tumor suppressor genes often involve chromosomal alterations that can be detected as loss of heterozygosity(a). In the Eker rat, spontaneous tumors of the kidney, uterus, and spleen develop as a result of a germline mutation of the tuberous
โฆ LIBER โฆ
Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis
โ Scribed by Masashi Mizuguchi; Masato Mori; Yasuyuki Nozaki; MarikoY. Momoi; Masayuki Itoh; Sachio Takashima; Okio Hino
- Book ID
- 106073014
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 612 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0001-6322
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## Abstract We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene(__Tsc2__), the gene predisposing to renal carcinoma(a) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably d
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