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Impact of gene-modified T cells on HIV infection dynamics

✍ Scribed by Dorothee von Laer; Susanne Hasselmann; Klaus Hasselmann

Book ID
108196088
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
601 KB
Volume
238
Category
Article
ISSN
0022-5193

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We analyse mathematical models comparing the in vivo dynamics of macrophage-and T cell infection by HIV. Experiments suggest that HIV can only replicate in activated T cells whereas cell activation may not be required for successful replication in macrophages. These assumptions lead to fundamentally