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T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients

✍ Scribed by Riddell, Stanley R.; Elliott, Mark; Lewinsohn, Deborah A.; Gilbert, Mark J.; Wilson, Linda; Manley, Sara A.; Lupton, Stephen D.; Overell, Robert W.; Reynolds, Thomas C.; Corey, Lawrence


Book ID
109927166
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
862 KB
Volume
2
Category
Article
ISSN
1078-8956

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## Abstract ## Background An anti‐HIV‐1 __tat__ ribozyme, termed Rz2, has been shown to inhibit HIV‐1 infection/replication and to decrease HIV‐1‐induced pathogenicity in T‐lymphocyte cell lines and normal peripheral blood T‐lymphocytes. We report here the results of a phase I gene transfer clinic