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Immunogenic effect of hepatitis B vaccine in children: Comparison of two-and three-dose protocols

✍ Scribed by Bernard Yvonnet; Pierre Coursaget; Eric Petat; Eric Tortey; Cheikh Diouf; Francis Barin; Francois Denis; Ibrahima Diop-Mar; Jean-Paul Chiron

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 183 KB
Volume: 14
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890140207

No coin nor oath required. For personal study only.

✦ Synopsis

The immunogenic effect of hepatitis B vaccine was evaluated in 183 seronegative infants from Senegal. Seventy-two seronegative infants received two 5-micrograms doses of vaccine at a two-month interval and 111 seronegative infants received three 5-micrograms doses at one-month intervals. All the children had a booster dose one year after the first injection of vaccine. No difference between the two groups was observed in the seroconversion rate (93.1% and 94.6%, respectively); in the proportion of high anti-HBs titer; or in the anti-HBs geometric mean titer (82 and 92 mIU/ml, respectively). These results demonstrate that two doses of 5 micrograms of hepatitis B vaccine are sufficient in infants to obtain a high immunogenic effect.

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