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Immunogenic effect of inactivated hepatitis B vaccine: Comparison of 20 μg and 40 μg doses

✍ Scribed by Saul Krugman; H. Preston Holley; J. R. Morton Davidson; Michael S. Simberkoff; Nicolas Matsaniotis

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
166 KB
Volume
8
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

The immunogenic effect of inactivated hepatitis B vaccine (Merck Heptavax B) was evaluated in 202 seronegative healthy medical personnel. Three inoculations of vaccine were given at 1‐month intervals. Of 116 vaccinees who received a 40‐μg dose, 39% had an anti‐HBs response 1 month after the first dose, 88% 1 month after the second dose, and 99% 1 month after the third dose. Of 86 vaccinees who received a 20‐μg dose, 40% had an anti‐HBs response 1 month after the first dose, 79% after the second dose, and 95% after the third dose. These results confirm the high immunogenic effect of a 20‐μg dose of vaccine.

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