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Immunogenic effect of inactivated hepatitis B vaccine: Comparison of 20 μg and 40 μg doses

✍ Scribed by Saul Krugman; H. Preston Holley Jr.; Morton Davidson; Michael S. Simberkoff; Nicolas Matsaniotis

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
166 KB
Volume
8
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

An outbreak of nonbacterial gastroenteritis occurred in an orphanage in December 1979. Of 54 residents, 43 were affected with acute gastroenteritis. Diarrhea was the commonest symptom. The 33‐ to 39‐nm virus‐like particles, tentatively designated as Sapporo agent, were detected in 17 (48.6%) of the patients' 35 fecal specimens. Morphologically, it was difficult to distinguish the Sapporo agent from other agents without geometrical pattern on the surface. Antigenically, the Sapporo agent related to the Otofuke agent detected in an outbreak of the institution for mentally retarded adults and also to the SRV '76 detected in familial cases of infectious gastroenteritis. The Sapporo agent might belong to a new group of those gastroenteritis viruses which were larger in size than the Norwalk virus group.

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