✦ LIBER ✦

Immunogenicity of low doses of hepatitis B vaccine in children: A study in 650 New Zealand children

✍ Scribed by Alexander Milne; Mary Dimitrakakis; Geoffrey Allwood; Ron Lucas; Chris Moyes; Neil Pearce

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 392 KB
Volume: 23
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890230413

No coin nor oath required. For personal study only.

✦ Synopsis

Six hundred and fifty New Zealand children from 2-12 years of age were vaccinated three times with 2 mcg intramuscular (IM) doses of Merck Sharp and Dohme plasma-derived hepatitis B vaccine (H-B-Vax), at 0, 1, and 6 months, and tested 2-3 months later for antibody to hepatitis B surface antigen (anti-HBs) by radioimmunoassay (RIA). Overall, 96.5% of the children seroconverted for anti-HBs by RIA, having levels greater than 2.1 RIA S/N units, with 91.2% having values greater than 10 S / N units. Anti-HBs levels were also determined by enzyme immunoassay (EIA), by which method a significantly better response was demonstrated in 24-year-olds than in older children. This study demonstrated that a satisfactory anti-HBs response was obtained using one-fifth of the recommended doses of hepatitis B vaccine.

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