✦ LIBER ✦

Immune complexes in hemophilia

✍ Scribed by Thomas R. Poskitt; Paula K. F. Poskitt; Cheryl A. Bean; Yale S. Arkel

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 398 KB
Volume: 11
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.2830110205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Circulating immune complexes (ICs), assayed by the L1210 enzyme‐linked immunoassay, were detected in 48% of patients with hemophilia A, 50% of patients with von Willebrand's disease, and in none of our patients with hemophilia B. Eighty‐five % of the hemophilia A and B patients had mild to moderate disease with only one patient demonstrating a circulating inhibitor. No correlation was found between IC levels and hepatitis B infection, SGOT, disease severity, total quantity of factor VIII or IX infused, time interval from last infusion, or rheumatoid factor positivity. Although the nature of the ICs is not known, the similarity of IC levels between hemophilia A and von‐Willebrand's disease is discussed with regard to antibodies generated to non‐procoagulant portions of the factor VIII molecule.

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