Immune complexes in hepatitis C

✍ Scribed by V Agnello

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 106 KB
• Volume: 26
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.510260648

✦ Synopsis

It is well established that in analyzing deposits of immune 2. Sansonno D, Gesualdo L, Manno C, Schena FP, Damacco F. Hepatitis C complexes containing rheumatoid factor in glomerular lesions, virus-related proteins in kidney tissue from hepatitis C virus infection the use of antibody probes for specific antigen produces false patients with cryoglobulinemia membranoproliferative glomerulonephritis. HEPATOLOGY 1997;25:1237-1244. positive results unless F(ab 1 ) 2 preparations of the antibodies 3. Maggiore Q, Bartolomeo F, L'Abbate A, Misefari V. HBsAg glomerular are used. 1 In their studies on membranoproliferative glomerudeposits in glomerulonephritis. Fact or artifact? Kidney Intern 1981;19: lonephritis (MPGN) in patients with mixed cryoglobulinemia 579-586. associated with hepatitis C virus (HCV) infections Sansonno 4. Hirose H, Udo K, Kojima M, Takahashi Y, Miyakawa Y, Miyamoto K, Yoshizewa H, et al. Deposition of hepatitis 8 antigen in membranous et al. 2 did not use F(ab 1 ) 2 preparations of the antibody probes. glomerulonephritis: identification by F(ab 1 ) 2 fragments in monoclonal It was clearly demonstrated, almost 20 years ago, that studies antibody. Kidney Int 1984;26:338-341. implicating hepatitis B surface antigen in MPGN associated 5. Agnello V, Abel G, Knight GB, Zhang QX, Elfahal M, Congalonieri R, with mixed cryoglobulinemia using commercial anti-hepatitis Montoli A, et al. The role of hepatitis C virus in the pathogenesis of type B surface antigen were artifactual, as shown by uniformly II cryoglobulinemia. Keystone Symposia on Hepatitis C and Beyond,