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Imatinib resistance in gastrointestinal stromal tumors

โœ Scribed by Lei L. Chen; Mahyar Sabripour; Robert H. I. Andtbacka; Shreyaskumar R. Patel; Barry W. Feig; Homer A. Macapinlac; Haesun Choi; Elsie F. Wu; Marsha L. Frazier; Robert S. Benjamin


Book ID
107546391
Publisher
Current Science Inc.
Year
2005
Tongue
English
Weight
812 KB
Volume
7
Category
Article
ISSN
1523-3790

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## Abstract __BRAF__ and __NRAS__ are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was shown to overexpress KIT and harbor __KIT__ mutations. Although most gastrointestinal stromal tumors (GISTs) exhibit activa