Imatinib induces a cytogenetic response in blast crisis or interferon failure chronic myeloid leukemia patients with e19a2 BCR-ABL transcripts
β Scribed by Lee, J-J; Kim, H-J; Kim, Y-J; Lee, S; Hwang, J-Y; Kim, Y-L; Kim, D-W
- Book ID
- 110055977
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 66 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
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## Abstract During the formation of the Philadelphia (Ph) chromosome, in the majority of chronic myelogenous leukemia (CML) patients, the chromosome 22 breakpoint is located in the major breakpoint cluster region of the BCR gene (Mβbcr). Minor and micro breakpoint cluster regions (mβbcr with e1a2 t
Since very few unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no clear evidence exists concerning their clinical and prognostic implications. We describe here a CML case with normal karyotype at standard cytogenetics and an atypical e6a2 BCR/ABL fusion transcript,