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Prolonged treatment with imatinib mesylate in patients with advanced chronic myeloid leukemia causes a reduction of bcr/abl mRNA levels independent of cytogenetic response

✍ Scribed by E. Cariani; M. Capucci; M. Micheletti; F. Spalenza; I. Zanella; A. Albertini; G. Rossi


Publisher
Springer
Year
2003
Tongue
English
Weight
114 KB
Volume
82
Category
Article
ISSN
0939-5555

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Imatinib mesylate (IM) therapy leads to a complete cytogenetic response (CCyR) in 75-90% of Chronic Myeloid Leukemia (CML) patients in chronic phase, but only a small percentage of patients achieve complete molecular response (CMR). Very little is known about IM discontinuation. We report the case o