Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib
✍ Scribed by Massimo Breccia; Laura Cannella; Daniela Diverio; Paola Streponi; Mauro Nanni; Caterina Stefanizzi; Fiammetta Natalino; Sergio Mecarocci; Giuliana Alimena
- Book ID
- 104040466
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 91 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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✦ Synopsis
Since very few unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no clear evidence exists concerning their clinical and prognostic implications. We describe here a CML case with normal karyotype at standard cytogenetics and an atypical e6a2 BCR/ABL fusion transcript, presenting at diagnosis isolated thrombocytosis and mild leukopenia; the patient, who was tested negative for JAK2 mutation, obtained a complete response to imatinib. The few previous observations from literature are also reviewed.