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Identity of the soluble ebv-associated antigens of human lymphoid cell lines

✍ Scribed by Beverley M. Reedman; J. H. Pope; D. J. Moss

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
1005 KB
Volume
9
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The reactions of human sera with antigens prepared from five human lymphoid cell lines were studied by immunodiffusion. Two major precipitation lines occurred with QIMR‐WIL antigens; one (S line) due to a soluble antigen and the other (F line) due to a sedimentable antigen. A close association in human sera of precipitins producing the S line with antibody to Epstein‐Barr virus (EBV) detectable by immunofluorescence (Henle test) and by complement fixation (CF) tests indicated a specific association of the S line with EBV, but the nature of the F line was not clarified. Soluble antigens prepared from five lymphoid cell lines (including Raji) contained at least one common identical heat‐resistant component, defined as the antigen giving the S line. The ease of detection of the S antigen in cell lines by immunodiffusion appeared to be related to the titre of the soluble EBV‐associated CF antigen, and the evidence suggested that the soluble CF and ID antigens were probably identical.

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