✦ LIBER ✦

Expression of tumor-associated antigens and kinetic profile of two in vitro human melanoma cell lines

✍ Scribed by G. Badaracco; A. Corsi; A. Maisto; P. G. Natali; G. Starace; G. Zupi

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 490 KB
Volume: 2
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.990020205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The growth characteristics and the antigenic profile of two human melanoma established cell lines in vitro are reported. The growth curves of the two cell lines show some peculiar features which are also detected in their DNA distribution content. In the late stages of growth, in fact, the cell DNA content resumes the initial distribution, suggesting a partial recovery of the cell proliferating potential. When the two cell lines were tested by indirect immunofluorescence with monoclonal antibodies to human melanoma associated antigens, a rather constant expression of these epithopes was observed.

📜 SIMILAR VOLUMES

Detection of tumor-associated antigen in

Detection of tumor-associated antigen in human melanoma cell line supernatants

✍ Elizabeth A. Grimm; Hulbert K. B. Silver; Jack A. Roth; Darwin O. Chee; Rishab K 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 477 KB

## Abstract Spent tissue culture medium (CDM‐S) removed from a single cell line of human malignant melanoma grown in serum‐free CDM, contained tumor‐associated antigenic activity. Antibodies to CDM‐S measured by complement fixation were detected in 44% (31/70) melanoma, 55% (15/27) sarcoma, 63% (24

Heterogeneity in expression of human leu

Heterogeneity in expression of human leukocyte antigens and melanoma-associated antigens in advanced melanoma

✍ Galen A. Ohnmacht; Francesco M. Marincola 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 2 views

The study of tumor immunology has led to many innovative therapeutic strategies for the treatment of melanoma. The strategies are primarily dependent on melanoma-associated antigen peptide vaccination or T-cell-based therapy. These immunotherapies are totally reliant on proper copresentation of huma

Coexpression of tumor-associated α2-macr

Coexpression of tumor-associated α2-macroglobulin and growth factors in human melanoma cell lines

✍ Alena Lizonová; Jozef Bízik; Marta Grófóva; Antti Vaheri 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 854 KB

a,-Macroglobulin ( a 2 M ) is known as an inhibitor of various proteinases and to bind several of the growth factors. W e previously demonstrated that clonal variation exists in the production of a,M in a human melanoma and that this variation may be associated with growth stimulation. We have now a

Expression of α2-macroglobulin receptor-

Expression of α2-macroglobulin receptor-associated protein in normal human epidermal melanocytes and human melanoma cell lines

✍ Yonghe Li; Nick Wood; David Yellowlees; Peter K. Donnelly 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 1 views

␣ 2 -Macroglobulin receptor/low-density lipoprotein receptor-related protein is a multifunctional cell surface receptor known to bind and internalize a large number of ligands. ␣ 2 -Macroglobulin receptor-associated protein acts as an intracellular ''chaperone'' for this receptor, and it has been sh

Expression of CD44 isoforms in human pro

Expression of CD44 isoforms in human prostate tumor cell lines

✍ Stevens, Jeff W.; Palechek, Patricia L.; Griebling, Tomas L.; Midura, Ronald J.; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 917 KB

We have examined the expression of the transmembrane glycoproteins CD44 in four human prostate tumor cell lines. Expression was examined at the protein level by flow cytometric analysis and Western blot, and at the mRNA level by reverse transcriptionpolymerase chain reaction (RT-PCR). All four cell

Expression profile of eukaryotic transla

Expression profile of eukaryotic translation factors in human cancer tissues and cell lines

✍ Pius Joseph; Christina M. O'Kernick; Sreekumar Othumpangat; Yi-Xiong Lei; Bao-Zh 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB

## Abstract Several studies have demonstrated the overexpression of certain eukaryotic translation factors in human cancer cell lines and in malignant tissues. In this study, with human cancer cell lines derived from lungs, breast, prostate, and skin, we have examined the expression profile of 36 t