Identity of BCA200 and c-erbB-2 indicated by reactivity of monoclonal antibodies with recombinant c-erbB-2
β Scribed by David B. Ring; Robin Clark; Amita Saxena
- Book ID
- 118384379
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 830 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0161-5890
No coin nor oath required. For personal study only.
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With the breast carcinoma cell line BT 474 used as a source of antigen, four rat monoclonal antibodies (MAbs) (3 IgG,, and I IgA) have been prepared against the external domain of the product of the c-erbB-2 proto-oncogene. All 4 antibodies stain frozen sections of tissues that over-express the prod
The cell-surface receptor tyrosine kinase protein c-erbB-2 is immunocytochemically detected as membrane staining on the surface of cancer cells in 20-30% of cases of breast cancer, and its presence has been associated with poor prognosis for the patient. However, there have been numerous reports of