The expression of c-erbB-1 and c-erbB-2 in Iranian patients with gastric carcinoma
β Scribed by Abbas Ghaderi; Mohammad Vasei; Sa Maleck-Hosseini; Behronz Gharesi-Fard; Maliheh Khodami; Mehrnoosh Doroudchi; Helmout Modjtahedi
- Publisher
- Springer Netherlands
- Year
- 2002
- Tongue
- English
- Weight
- 435 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1219-4956
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One hundred seventy-nine primary human gastric tumors not associated with early cancer or noncurative resection were examined immunohistochemically for the expression of c-erbB-2 protein. Positive staining, regarded as an indication of gene amplification, was evident in 22( 12%) of the tumors. Of va
## Background: Recently, the extracellular domain of the c-erbb-2 oncogene product (her-2/neu) has been reported to be elevated in the serum of one-fourth of patients with metastatic breast carcinoma. the role of serum c-erbb-2 as a tumor marker, however, is still poorly defined. the purpose of thi