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Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood

✍ Scribed by Ana Teresa Maia; Roxane Tussiwand; Giovanni Cazzaniga; Paolo Rebulla; Susan Colman; Andrea Biondi; Mel Greaves

Book ID: 102219868
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 166 KB
Volume: 40
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.20010

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✦ Synopsis

Abstract

Previous studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that common chromosome translocations of pediatric leukemia frequently arise before birth. The IGH/TCR clonotypic sequences used as surrogate molecular markers suggest this is also likely to be true for hyperdiploid acute lymphoblastic leukemia (ALL). Yet evidence that hyperdiploidy itself is an early or initiating event occurring prenatally has been limited. Now, however, we can provide direct evidence of this from our identification of CD34^+^/CD19^+^ B‐lineage progenitor cells with triploid chromosomes in the stored cord blood of an individual who subsequently developed hyperdiploid ALL. © 2004 Wiley‐Liss, Inc.

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