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Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins

✍ Scribed by Maia, A T; van der Velden, V H J; Harrison, C J; Szczepanski, T; Williams, M D; Griffiths, M J; van Dongen, J J M; Greaves, M F

Book ID
110055631
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
127 KB
Volume
17
Category
Article
ISSN
0887-6924

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Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. The peak incidence of ALL between ages 2 and 5 is accounted for by one subtype, referred to as common acute lymphoblastic leukemia (cALL). About 25% of cALL patients have the TEL-AML1 gene fusion derived from the t(12;21