Prenatal origin of separate evolution of leukemia in identical twins
✍ Scribed by Dettling, M; Schaub, R; Schäfer, B W; Niggli, F K; Teuffel, O; Betts, D R
- Book ID
- 110055985
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 219 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
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## Abstract Previous studies on concordant acute lymphoblastic leukemia (ALL) in identical twins have identified the leukemia as monoclonal with __MLL__ or __ETV__6‐__RUNX1__ gene fusion as early or initiating events in utero. In the latter case, postnatal latency is associated with secondary genet
## Abstract We report detailed immunological, cytogenetic and molecular evidence for complete identity of the leukemic cell populations in monozygotic female twins with concordant leukemia diagnosed at two months of age. Both infants had early pre‐B acute lymphoblastic leukemia with the (11;19)(q23