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Investigation of clonal involvement of myeloid cells in Philadelphia-positive and high hyperdiploid acute lymphoblastic leukemia

โœ Scribed by Kasprzk, A

Book ID
110054513
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
27 KB
Volume
14
Category
Article
ISSN
0887-6924

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The Philadelphia chromosome (Ph) is found in both chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). The Ph translocation, t(9;22)(q34;qll), can disrupt the BCR gene on chromosome 22 in one to two areas called the major (Mbcrl) and minor (mbcrl) breakpoint cluster regions. In CML

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We have previously described a patient in whom the breakpoint occurred within the first intron of the BCR gene and have cloned the 9q+ and 22q-junctions. We have now determined the nucleotide sequence around the breakpoints on both translocation products from this patient as well as the correspondin