Investigation of clonal involvement of myeloid cells in Philadelphia-positive and high hyperdiploid acute lymphoblastic leukemia
โ Scribed by Kasprzyk, A; Harrison, CJ; Secker-Walker, LM
- Book ID
- 110054364
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 138 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0887-6924
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๐ SIMILAR VOLUMES
The Philadelphia chromosome (Ph) is found in both chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). The Ph translocation, t(9;22)(q34;qll), can disrupt the BCR gene on chromosome 22 in one to two areas called the major (Mbcrl) and minor (mbcrl) breakpoint cluster regions. In CML
We have previously described a patient in whom the breakpoint occurred within the first intron of the BCR gene and have cloned the 9q+ and 22q-junctions. We have now determined the nucleotide sequence around the breakpoints on both translocation products from this patient as well as the correspondin