Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia
β Scribed by Terre, C; Eclache, V; Rousselot, P; Imbert, M; Charrin, C; Gervais, C; Mozziconacci, M J; Maarek, O; Mossafa, H; Auger, N
- Book ID
- 110055923
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 126 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0887-6924
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## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)βnegative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon
## Abstract ## BACKGROUND. Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)βnegative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate. In some patients, CCA/Phβnegative status was associated with