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Clonal aberrations in Philadelphia chromosome negative hematopoiesis in patients with chronic myeloid leukemia treated with imatinib or interferon alpha

✍ Scribed by Schoch, C; Bacher, U; Hochhaus, A; Berger, U; Hiddemann, W; Hehlmann, R; Haferlach, T

Book ID: 110056130
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 88 KB
Volume: 19
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2403607

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## Abstract ## BACKGROUND Anecdotal cases of chromosomal abnormalities in Philadelphia chromosome (Ph)‐negative metaphases have been reported in patients with chronic myelogenous leukemia (CML) in the chronic phase during treatment with interferon and, more recently, with imatinib. This phenomenon