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Identification of polysaccharides in pharmaceuticals by capillary gas chromatography

โœ Scribed by G. Vanlaeke; H. Cuppens; L. Leyssens; J. Raus

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
583 KB
Volume
7
Category
Article
ISSN
0731-7085

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โœฆ Synopsis

A sensitive method for the identification of polysaccharides in pharmaceuticals is described. Polysaccharides are isolated by gel filtration and subsequently hydrolysed. The monomeric carbohydrates obtained are transformed into oxime-trimethylsilyl derivatives and analysed by capillary gas chromatography. Profiles of 13 different natural or semi-synthetic polysaccharides are discussed. The profiles of the hydrolysis products can be used to identify the polysaccharides mentioned above. Possible interferences by other polymers are given. The method can be used to identify most polysaccharides used as pharmaceutical adjuvants.

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