Enantiomer separation of pharmaceuticals by capillary gas chromatography with novel chiral stationary phases

✍ Scribed by Iwao Abe; Kennji Terada; Taketoshi Nakahara

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 75 KB
• Volume: 14
• Category: Article
• ISSN: 0269-3879
• DOI: 10.1002/(sici)1099-0801(200004)14:2<125::aid-bmc940>3.0.co;2-c

✦ Synopsis

New chiral stationary phases of polydimethylsiloxane anchored with (S)-(À)-t-leucine derivatives were provided for use in enantiomer separation of pharmaceuticals by capillary gas chromatography. Fifteen pharmaceuticals were separated into their enantiomeric pairs by converting them into pentafluoropropionyl and heptafluorobutyryl derivatives. The separation factor and resolution obtained from the new phases were superior to those from the conventional Chirasil-Val capillary column.