Identification of phenobarbital N-glucosides as urinary metabolites of phenobarbital in mice
β Scribed by William H. Soine; Phyllis J. Soine; Terry M. England; John W. Ferkany; Bruce E. Agriesti
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 628 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
5-Ethyl-5-(4-hydroxy-3-methoxyphenyl) barbituric acid was identified as a new, minor metabolite of phenobarbital in man. The identity of this O-methylcatechol metabolite was confirmed by an unequivocal chemical synthesis, and by GC-MS studies. Mephobarbital and the 1,3-dimethyl, 1-ethyl, and 1,3-die
Complexes of phenobarbital with quinine, quinidine, or hydroquinidine have been prepared and characterized. By means of infrared spectroscopy, these complexes were differentiated from physical mixtures of their respective components when the drug was examined either alone or in harmaceutical dosage