Identification of complexes of phenobarbital with quinine, quinidine, or hydroquinidine in pharmaceutical dosage forms
✍ Scribed by W. N. French; J. C. Morrison
- Publisher
- John Wiley and Sons
- Year
- 1965
- Tongue
- English
- Weight
- 407 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
Complexes of phenobarbital with quinine, quinidine, or hydroquinidine have been prepared and characterized. By means of infrared spectroscopy, these complexes were differentiated from physical mixtures of their respective components when the drug was examined either alone or in harmaceutical dosage forms. Of four commercial preparations examined, only tfree were found to contain true complexes. In contact with simulated gastric juice, the complexes were shown to be readily decomposed, regenerating the sedative and alkaloid from which they were formed.
HENOBARBITAL is known to react with organic bases such as 2-amino-1-phenylpropane,