Identification of multiple molecular genetic alterations in bladder cancer
β Scribed by M.A. Knowles; J.P. Cairns; M.P. Williamson; A.J. Proctor; L.M. Coombs; M.E. Eydmann
- Book ID
- 119105662
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 85 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0165-4608
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Bladder cancer i s the result of a clonal expansion of cancer cells in which multiple genetic alterations have accumulated. Point mutations of the p53 gene are frequently observed in bladder cancer. Loss of a retinoblastoma (Rb) allele is also common in bladder cancer. Recent data have shown frequen