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Genetic alterations and biological pathways in human bladder cancer pathogenesis

✍ Scribed by Catherine A Reznikoff; Somdatta Sarkar; Knut P Jülicher; Melissa S Burger; Jairaj A Puthenveettil; David F Jarrard; Michael A Newton

Book ID
117724097
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
556 KB
Volume
5
Category
Article
ISSN
1078-1439

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✍ Li Mao 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 551 KB

Bladder cancer i s the result of a clonal expansion of cancer cells in which multiple genetic alterations have accumulated. Point mutations of the p53 gene are frequently observed in bladder cancer. Loss of a retinoblastoma (Rb) allele is also common in bladder cancer. Recent data have shown frequen