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Genetic alterations in bladder cancer

✍ Scribed by G. Dalbagni; J. Presti; W.R. Fair; V. Reuter; C. Cordon-Cardo


Book ID
119066258
Publisher
The Lancet
Year
1993
Tongue
English
Weight
442 KB
Volume
342
Category
Article
ISSN
0140-6736

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Bladder cancer i s the result of a clonal expansion of cancer cells in which multiple genetic alterations have accumulated. Point mutations of the p53 gene are frequently observed in bladder cancer. Loss of a retinoblastoma (Rb) allele is also common in bladder cancer. Recent data have shown frequen