Bladder cancer can be viewed as a prototype for carcinogen-induced neoplasia. This has been demonstrated experimentally in a variety of systems and in man through epidemiological studies of occupational exposure to putative carcinogens. The natural history of this neoplasm demonstrates recurrence in
✦ LIBER ✦
Molecular alterations in bladder cancer
✍ Scribed by Ørntoft, Torben F. ;Wolf, Hans
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 346 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0300-5623
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Bladder cancer i s the result of a clonal expansion of cancer cells in which multiple genetic alterations have accumulated. Point mutations of the p53 gene are frequently observed in bladder cancer. Loss of a retinoblastoma (Rb) allele is also common in bladder cancer. Recent data have shown frequen