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Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein

✍ Scribed by Priv.-Doz. Dr. med. Karin Dilger; Matthias Schwab; Martin F. Fromm


Book ID
110086259
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
224 KB
Volume
10
Category
Article
ISSN
1078-0998

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Contribution of the murine mdr1a P-glyco
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In the mouse, both the mdr1a and the mdr1b gene encode drug-transporting P-glycoproteins. The mdr1a P-glycoprotein is expressed in epithelial cells of, among others, the liver and the intestine. Furthermore, the mdr1b gene product is found in the liver but is not detectable in the intestine. To esta