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Effects of Grapefruit Juice and Orange Juice on the Intestinal Efflux of P-Glycoprotein Substrates

โœ Scribed by Run Tian; Noriko Koyabu; Hitomi Takanaga; Hirotami Matsuo; Hisakazu Ohtani; Yasufumi Sawada


Book ID
110345642
Publisher
Springer US
Year
2002
Tongue
English
Weight
163 KB
Volume
19
Category
Article
ISSN
0724-8741

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Grapefruit juice and orange juice effect
โœ John S. Grundy; Lise A. Eliot; Ken M. Kulmatycki; Robert T. Foster ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 157 KB ๐Ÿ‘ 2 views

Previous studies with rats indicate that nifedipine undergoes both hepatic and extrahepatic presystemic metabolism after peroral (po) administration, and that its bioavailability is increased and absorption delayed by concomitant administration of grapefruit juice concentrate (GJC). Hence, the effec