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The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: The role of gut CYP3A and P-glycoprotein

โœ Scribed by Marika Pasternyk Di Marco; David J Edwards; Irving W Wainer; Murray P Ducharme

Book ID
117173616
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
156 KB
Volume
71
Category
Article
ISSN
0024-3205

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Grapefruit juice and orange juice effect
Grapefruit juice and orange juice effects on the bioavailability of nifedipine in the rat
โœ John S. Grundy; Lise A. Eliot; Ken M. Kulmatycki; Robert T. Foster ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 157 KB ๐Ÿ‘ 2 views

Previous studies with rats indicate that nifedipine undergoes both hepatic and extrahepatic presystemic metabolism after peroral (po) administration, and that its bioavailability is increased and absorption delayed by concomitant administration of grapefruit juice concentrate (GJC). Hence, the effec