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Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol

✍ Scribed by H Spahn-Langguth; P Langguth

Book ID
114301822
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
89 KB
Volume
12
Category
Article
ISSN
0928-0987

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Grapefruit juice–drug interactions: Grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells
✍ Whocely Victor de Castro; Susanne Mertens-Talcott; Hartmut Derendorf; Veronika B πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 163 KB

To investigate the potential interaction between selected ingredients of grapefruit juice and, the transport of talinolol, a P-gp substrate, across Caco-2 cells monolayers was determined in the absence and presence of distinct concentrations of grapefruit juice, bergamottin, 6 0 ,7 0 -dihydroxyberga