Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation
โ Scribed by Makoto Kataoka; Tomonori Yokoyama; Yoshie Masaoka; Shinji Sakuma; Shinji Yamashita
- Book ID
- 113592525
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 398 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0928-0987
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๐ SIMILAR VOLUMES
The intestinal efflux pump, P-glycoprotein (P-gp), located in the apical membranes of intestinal absorptive cells, can reduce the bioavailability of a wide range of drugs which are substrates for this membrane transporter. In addition to anticancer and anti-HIV drugs, NCEs for other disease indicati
The absorptive (AQ) and secretory (SQ) quotients have been proposed as a novel experimental approach to quantify the modulation of intestinal absorption and secretion by P-glycoprotein (Pgp). Because these unidirectional assays inherently assess for the impact of Pgp, conclusions as to whether a com