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Identification of a Chromosomal Breakpoint and Detection of a Novel Form of anMLL- AF17Fusion Transcript in Acute Monocytic Leukemia with t(11;17)(q23;q21)

✍ Scribed by Kazumi Suzukawa; Seiichi Shimizu; Noriko Nemoto; Naoko Takei; Tomohiko Taki; Toshiro Nagasawa

Book ID: 111835452
Publisher: Carden Jennings Publishing
Year: 2005
Tongue: English
Weight: 504 KB
Volume: 82
Category: Article
ISSN: 0925-5710
DOI: 10.1532/ijh97.05025

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## Abstract We have identified a novel fusion partner of __MLL__, namely the mastermind like 2 (__MAML____2__ gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RT‐PCR and sequencing revealed that exon 7 of __MLL__ was fused to exon 2 of __MAML