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Molecular Identification of a New Splicing Variant of the MLL-MLLT11 Fusion Transcript in an Adult with Acute Myeloid Leukemia and t(1;11)(q21;q23)

✍ Scribed by Lee, Sang-Guk; Park, Tae Sung; Yang, John Jeongseok; Oh, Seung Hwan; Cho, Eun Hae; Lee, Sanggyu; Oh, Doyeun; Huh, Ji Young; Marschalek, Rolf; Meyer, Claus

Book ID
118142083
Publisher
S. Karger AG
Year
2012
Tongue
English
Weight
923 KB
Volume
128
Category
Article
ISSN
0001-5792

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## Abstract We have identified a novel fusion partner of __MLL__, namely the mastermind like 2 (__MAML____2__ gene), in secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) with inv(11)(q21q23). RT‐PCR and sequencing revealed that exon 7 of __MLL__ was fused to exon 2 of __MAML