Identification of 2-amino-6-O-(2-amino-2-deoxy-β-d-glucopyranosyl)-2-deoxy-d-glucose as a major constituent of the hydrophobic region of the Bordetella pertussis endotoxin
✍ Scribed by Martine Caroff; Ladislas Szabó
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 560 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0008-6215
No coin nor oath required. For personal study only.
✦ Synopsis
2-Amino-6-0-(2-amino-2-deoxy-~-D-glucopyranosyl)-2-deoxy-D-glucose substituted on the amino group of the reducing 2-amino-2-deoxy-D-glucose unit by a 3-hydroxytetradecanoyl group was shown to be a major constituent of the "Lipid A" fragment obtained by acid hydrolysis of the Bordetella pertussis endotoxin.
📜 SIMILAR VOLUMES
The synthesis of the glycosyl-mya-inositol l-phosphates 1 and 2 and of the glycosyl-myoinositol 1,2-(cyclic phosphate) 3, starting from previously synthesized intermediates, is reported. Compound 3 was found to display proliferative effects on the early developing inner ear of chick embryo.
The crystal and molecular structures of 2-amino-2-deoxy-a/fl-D-glucopyranose 3-sulfate (1) and 2-amino-2-deoxy-fl-D-glucopyranose 6-sulfate (2) have been determined by direct methods. The sugar rings have the expected 4C1 conformation and the geometries of the sulfate groups are comparable with thos
Studies on the Fast Atom
The electron-impact (e.i.) and chemical-ionization (ci.) mass spectra of the 2-di-N-methyl (2) 2-N-acetyl (3), and 2-(N-acetyl)-N-methyl (4) derivatives of 1,5-di-O-acetyl-7-O-(2-amino-2-deoxy-3,4,6-tri-O-methyl-~-D-glucopyranosyl)-2,3,4,6-tetra-O-methyl-L-glycero-D-manno-heptitol, obtained from the